Antioxidant, Anti-inflammatory, Antiproliferative and Antimicrobial Activities of Combretum glutinosum and Gardenia aqualla Extracts in vitro


Free Radicals and Antioxidants,2019,9,2,66-72.
Published:December 2019
Type:Original Article
Author(s) affiliations:

Bawa Yusuf Muhammad1,2,*, Nadia Zaky Shaban1, Fatima Hassan Elrashidy1, Doaa Ahmed Ghareeb1,3

1Department of Biochemistry, Faculty of Science, Alexandria University, Alexandria, EGYPT.

2Department of Biochemistry and Molecular Biology, Faculty of Science, Nasarawa State University Keffi, NIGERIA.

3Bioanalytical centres of Excellence: Pharmaceutical and fermentation Department, GEBRI, SRAT-city, Alexandria, EGYPT.


Objectives: Plants represent a diverse template that could be tapped as sources of novel drugs. This study highlights antioxidant, anti-inflammatory, anti-proliferative and as well antimicrobial activities of Combretum glutinosum (BE) and Gardenia aqualla (GE) roots ethanol extracts. Methods: The Biological activities were evaluated using the established standard methods. Results: Both extracts exhibited antioxidant and anti-inflammatory activities with BE being better than GE. Anti-proliferative (cytotoxicity) assay on HepG2 and BHK-21 cell lines similarly revealed that BE (IC50: 55, SI: 1.81) is more cytotoxic and more selective than GE (IC50: 478.60, SI: 0.99). For the antimicrobial study, BE inhibited the growth of pathogenic bacteria; Pseudomonas aeruginosa, Staphylococcus aureus, Vibrio species and E. coli, while GE extract showed activity against Candida albicans. Conclusion: We conclude that Combretum glutinosum extract (BE) possessed the most robust activity from this study. Hence, it could be a promising source of novel drug with wide biological activities, especially antioxidant and anticancer activities.