Glutamate Receptors in Schizophrenia: A Review

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Abstract
Free Radicals and Antioxidants,2020,10,1,01-03.
Published:August 2020
Type:Review Article
Authors:
Author(s) affiliations:

Shivani Lodha1,*, Shagun Upadhyay2, Khemraj Singh Baghel3, Yusra Ahmad1

1Faculty of Pharmacy, Uttarakhand Technical University, Dehradun, Uttarakhand, INDIA.

2Department of Pharmacy, Kalaniketan Polytechnic College, Jabalpur, Madhya Pradesh, INDIA.

3Molecular Pathology Scientist, Biogenex Life Science Pvt. Ltd. Adibatla, Telangana, INDIA.

Abstract:

The pathophysiology of schizophrenic shows the dysfunction of Glutamate receptors. The inotropic subtypes The NMDA, AMPA and kinate receptors out of various glutamate receptors are most commonly associated. In postmortem brain samples from schizophrenics and controls several levels of gene expression of glutamate receptors were studied. Even though there exist slight inconsistency from various studies certain points. There is an abnormal reduction in the AMPA receptor expression in the schizophrenic hippocampus, including reduced subunit transcript level, protein level and also binding sites. In hippocampus related changes are also seen in the kinate receptor expression. In some cortical regions in schizophrenia NMDAR1 shows abnormal expression. NMDDAR1 is the obligate NMDA receptor subunit. The current review ellustrates the theory of glutamate neurotransmission abnormality in schizophrenia.

Cite This Article

Vancouver Style :: Lodha S, Upadhyay S, Baghel KSingh, Ahmad Y. Glutamate Receptors in Schizophrenia: A Review. Free Radicals and Antioxidants. 2020;10(1):01-03.  (115.37 KB)
MLA Style: Lodha S, Upadhyay S, Baghel KSingh, Ahmad Y. Glutamate Receptors in Schizophrenia: A Review. Free Radicals and Antioxidants. 2020;10(1):01-03.  (115.37 KB)
CSE Style: Lodha S, Upadhyay S, Baghel KSingh, Ahmad Y. Glutamate Receptors in Schizophrenia: A Review. Free Radicals and Antioxidants. 2020;10(1):01-03.  (115.37 KB)
APA Style: Lodha S, Upadhyay S, Baghel KSingh, Ahmad Y. Glutamate Receptors in Schizophrenia: A Review. Free Radicals and Antioxidants. 2020;10(1):01-03.  (115.37 KB)