Antioxidant, Antimutagenic and Cytotoxic Properties of Essential Oil from Corchorus olitorius L. Flowers and Leaf

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Abstract
Free Radicals and Antioxidants,2016,6,1,34-43.
Published:4th Aug 2015
Type:Original Article

Antioxidant, Antimutagenic and Cytotoxic Properties of Essential Oil from Corchorus olitorius L. Flowers and Leaf

Dorra Driss1,2*, Mohamed Kaoubaa1, Riadh Ben Mansour3, Fatma Kallel1, Baha eddine Abdelmalek1 and Semia Ellouz Chaabouni1,2

1Unité Enzymes et Bioconversion, Ecole Nationale d’Ingénieurs de Sfax, Université de Sfax, route de Soukra 3038, Sfax, Tunisia.

2Unité de service commun bioréacteur couplé à un ultrafiltre, Ecole Nationale d’Ingénieurs de Sfax, Université de Sfax, route de Soukra 3038, Sfax, Tunisia.

3Biotechnology and pathologies Unit, Higher Institute of Biotechnology of Sfax, B.P. 1175, 3038 Sfax, Tunisia.

Abstract:

Background: This present research highlight the phytochemical profile, the antioxidant, the antimicrobial, the antimutagenic and the antiproliferative activities of an essential oil extracted from Corchorus olitorius L. flowers and leaf (COFL), an aromatic plant widely distributed in Tunisia and used as a traditional food plant. Results: Gas chromatography/ mass spectrometry was used to determine the composition of the COFL essential oil (COFL-EO). Forty-three components were identified and the main compounds were benzaldehyde (56%), methyl 4-methoxysalicylate (6.55%) and carvacrol (4.75%). The COFL-EO was also found to possess antioxidant activities, as evaluated by the 1,1-diphenyl-2-picrylhydrazyl (DPPH) radical method and β-carotene bleaching assay. The antibacterial activities showed good growth inhibition compared to positive controls. The diameter of the inhibition zones reached a maximum of 16.7 ± 0.1 mm when tested against Salmonella typhimurium using just 6 mg extract. On the other hand, the antimutagenic activity was assessed using the Ames Salmonella/microsome mutagenicity test and the COLF-EO exhibited high antimutagenic effects at 0.125, 0.0125 and 0.00125 mg/plate. Antiproliferative activity of this essential oil evaluated in four mammalian cells lines was significantly stronger in Hela cell line (IC50=4 ± 0.98 μg/mL). Conclusion: Overall, results presented here suggest that the COFL-EO is a potential new source of active ingredients for food and pharmaceutical industry.

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Founded:  In 2004, as the PHCOG.NET – a non-profit private organization dedicated to Natural Products Research leading to develop promising drugs. Our main mission is to make information on herbal drug research readily available in different formats to suit the individual needs. About Journal : Free Radicals and Antioxidants [ISSN: 2231-2536] is an online peer reviewed publication dedicated to publishing novel, original findings in the field of free radical biology and both natural and synthetic antioxidants. Free radicals, which are defined as molecules containing one or more unpaired electrons in their outmost atomic or molecular orbital have emerged as double edged swords.The Free Radicals and Antioxidants Journal aims to foster the dissemination of scientific information by publishing manuscripts that provide new insights into the biology of free radicals, including their generation, degradation, modulation, role in cellular function and cell signaling. The submission of uninvited expert reviews and research articles in all areas of Free Radical Biology and Antioxidants are also welcomed. Free Radicals and Antioxidants publishes full research papers presenting original, high quality research, critical review articles providing comprehensive analysis of research development within a defined area and editorial commentaries on key topical issues in Free Radical and Antioxidant Biology.
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