Distinct Antioxidant Activity of a Common Antidepressant Drug Imipramine

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Abstract
Free Radicals and Antioxidants,2016,6,2,151-154.
Published:Jan/2016
Type:Original Article

Distinct Antioxidant Activity of a Common Antidepressant Drug Imipramine

Debalina Sinharoy1, Debanjan Mukhopadhyay2, Shauroseni Palchoudhuri1, Bidisha Ghosh3, Sukhen Das3, Sujata G. Dastidar1*

1Department of Microbiology, Herbicure Healthcare Bio-Herbal Research Foundation, Saraldighi (E), Boral, Kolkata-700154, INDIA.

2Department of Molecular Biology, Herbicure Healthcare Bio-Herbal Research Foundation, Saraldighi (E), Boral, Kolkata- 700154, INDIA.

3Department of Physics, Jadavpur University, Kolkata- 700032, INDIA.

Abstract:

Background: Free radicals are known to cause severe damage to most of the biomolecules in the human system and are responsible for various illnesses including neurodegenerative, cardiovascular and autoimmune disorders. Antioxidants can reduce effects of free radicals and are given to patients suffering from such diseases. There are certain natural antioxidants like flavonoids which possess free radical scavenging activities. The flavonoid quercetin is one such compound among naturally occurring antioxidants. The present study has been designed to determine the antioxidant activity in the synthetic antidepressant drug imipramine which is structurally similar to quercetin. Method: Specific standard procedures like ferric ion reducing capacity by FRAP assay, phosphomolybdenum assay and cupric ion reducing (CUPRAC) assay were carried out keeping ascorbic acid as the known standard. Results: Ferric ion reducing property of imipramine by FRAP assay revealed that reducing power of imipramine augmented with increasing amounts of the drug. In the phosphomolybdenum assay antioxidant capacity of imipramine increased in a dose dependent manner. In both these studies imipramine showed greater antioxidant action than ascorbic acid. In CUPRAC assay as the amount of imipramine was increased there was a definite elevation in antioxidant activity; however, it was comparatively less active than ascorbic acid. Conclusion: The highly potent antioxidant property in the antidepressant synthetic compound imipramine may be recognized by physicians involved in treatment of psychosis since patients receiving this drug regularly will certainly be in an advantageous position. The parent structure of imipramine can be modified further to potentiate antioxidant property of the drug.

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Founded:  In 2004, as the PHCOG.NET – a non-profit private organization dedicated to Natural Products Research leading to develop promising drugs. Our main mission is to make information on herbal drug research readily available in different formats to suit the individual needs. About Journal : Free Radicals and Antioxidants [ISSN: 2231-2536] is an online peer reviewed publication dedicated to publishing novel, original findings in the field of free radical biology and both natural and synthetic antioxidants. Free radicals, which are defined as molecules containing one or more unpaired electrons in their outmost atomic or molecular orbital have emerged as double edged swords.The Free Radicals and Antioxidants Journal aims to foster the dissemination of scientific information by publishing manuscripts that provide new insights into the biology of free radicals, including their generation, degradation, modulation, role in cellular function and cell signaling. The submission of uninvited expert reviews and research articles in all areas of Free Radical Biology and Antioxidants are also welcomed. Free Radicals and Antioxidants publishes full research papers presenting original, high quality research, critical review articles providing comprehensive analysis of research development within a defined area and editorial commentaries on key topical issues in Free Radical and Antioxidant Biology.
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Subjects Covered : Natural Products, Free Radical Biology, Antioxidants
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