Antioxidant, Antibacterial Activities and Identification of Bioactive Compounds from Terminalia chebula Bark Extracts


Free Radicals and Antioxidants,2017,7,1,43-49.
Published:September 2016
Type:Original Article

Antioxidant, Antibacterial Activities and Identification of Bioactive Compounds from Terminalia chebula Bark Extracts

Alagesan Venkatesan1, Arumugam Kathirvel2, Shanmugam Prakash1, Venugopal Sujatha1*

1Phytochemistry Lab, Department of Chemistry, Periyar University, Periyar Palkalai Nagar, Salem-636 011, Tamil Nadu, INDIA.

2Department of Chemistry, K. S. Rangasamy College of Arts and Science (Autonomous), Tiruchengode-637 215, Tamil Nadu, INDIA.


Background: Free radical induces numerous diseases by damaging biomolecules such as lipids, proteins, RNA and DNA. Several scientists reported that numerous plants and plant extracts have potent antioxidant activities to scavenge free radicals. The present study was aimed to screen phytoconstituents, in vitro antioxidant and antibacterial potential in various solvent extracts of Terminalia chebula bark. Methods: Phytochemical analysis, estimation of various metabolites, in vitro antioxidant and antibacterial activity were done by adopting standard protocols. Selected bioactive (acetone) extract of T. chebula was analyzed for their phytochemical profile by GC-MS analysis. Results: The results of preliminary phytochemical screening analysis revealed that presence of various phytochemicals like, alkaloids, flavonoids, glycosides, terpenoids, phenolics, saponins and carbohydrates in most of the tested extracts. Acetone extract possess significant high quantity of both primary and secondary metabolites when compared with other extracts. Remarkable free radicals scavenging potential was observed in acetone extract with lowest IC50 values on all tested radicals namely, DPPH. (IC50=144.77 μg/ml), NO. (IC50=149.46 μg/ml), .OH (IC50=121.18 μg/ml), O2 .- (IC50=159.41 μg/ml), Reducing power (IC50=35.85 μg/ml), Fe2+ ion chelating (IC50=137.56 μg/ml) and TBARS (IC50=201.96 μg/ml). Acetone extract expressed significant high antibacterial activity against S. typhi (15 mm). The result of GC-MS analysis of acetone extract shows the presence of 32 major bioactive compounds, including various phenolic, sesquiterpene, flavonoid, triazine and gibberellin compounds. Conclusion: The present study suggested that T. chebula bark extract serves as a good source of phytochemicals, natural antioxidant and antibacterial agent.

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Founded:  In 2004, as the PHCOG.NET – a non-profit private organization dedicated to Natural Products Research leading to develop promising drugs. Our main mission is to make information on herbal drug research readily available in different formats to suit the individual needs. About Journal : Free Radicals and Antioxidants [ISSN: 2231-2536] is an online peer reviewed publication dedicated to publishing novel, original findings in the field of free radical biology and both natural and synthetic antioxidants. Free radicals, which are defined as molecules containing one or more unpaired electrons in their outmost atomic or molecular orbital have emerged as double edged swords.The Free Radicals and Antioxidants Journal aims to foster the dissemination of scientific information by publishing manuscripts that provide new insights into the biology of free radicals, including their generation, degradation, modulation, role in cellular function and cell signaling. The submission of uninvited expert reviews and research articles in all areas of Free Radical Biology and Antioxidants are also welcomed. Free Radicals and Antioxidants publishes full research papers presenting original, high quality research, critical review articles providing comprehensive analysis of research development within a defined area and editorial commentaries on key topical issues in Free Radical and Antioxidant Biology.
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