Clinical Attestation and Redox Mechanism of Ascorbic Acid in the Treatment of Cancer
Keywords:Ascorbic acid, Reactive oxygen species (ROS), Intravenous, Angiogenesis, Clinical
Ascorbic acid (Vitamin C) is an essential micro-nutrient, an outstanding antioxidant and an essential co-factor in different mammalian enzymatic processes. There is considerable clinical attestation that, high dose of intravenous ascorbic acid can improve cancer patients with or without extant therapeutic involvements. Ascorbic acid in high intravenous doses serves as pro-oxidant and promotes the generation of hydrogen peroxide (H2O2) and other reactive oxygen species (ROS) with oxidative stress-induced toxicity selectively to cancer cells. This effect also hampers the bioenergetics and angiogenesis of malignant cells, resulting in cancer cell death. Large doses of ascorbic acid are safe and well-tolerated. On account of its antioxidant effect, ascorbic acid supplementation may be applied as an adjuvant with regular cancer therapy to minimize complications. Nevertheless, there is a necessity for further mechanistic studies and randomized controlled clinical trials to evaluate the benefit of ascorbic acid in the treatment of cancer.