Correlation of Anticancer Effects of 12 Iranian Herbs on Human breast Adenocarcinoma cells with antioxidant Properties

Authors

  • Reyhane Hoshyar Department of Biochemistry, Faculty of Medicine, Metabolism & Antioxidants Research Center, Birjand University of Medical Sciences, Birjand,
  • Seyedeh Elham Mostafavinia Department of Biochemistry, Faculty of Medicine, Birjand University of Medical Sciences, Birjand,
  • Asghar Zarban Department of Biochemistry, Faculty of Medicine, Metabolism & Antioxidants Research Center, Birjand University of Medical Sciences, Birjand, Iran
  • Mohammad Hassanpour Department of Pharmacology, Faculty of Medicine, Birjand University of Medical Sciences, Birjand,
  • Mozhde Partovfari Department of Biology, College of Sciences, Shiraz University, Shiraz,
  • Amir Taheri Metabolism & Antioxidants Research Center, Birjand University of Medical Sciences, Birjand,
  • Mohsen Pouyan Department of plant protection, Jihad-Agriculture Education Centre of South Khorasan,

DOI:

https://doi.org/10.5530/fra.2015.2.4

Keywords:

Anticancer, Antioxidant, MCF-7 cells, MCF-10A cells, Herbs

Abstract

Introduction: Many of Medicinal plants have been investigated for possible anticancer properties. The correlation cytotoxic effect of herbs with antioxidant activity is unclear, yet. The aim of the present study was to examine the antioxidant contents and anticancer effects of 12 Iranian medicinal plants on proliferation of breast cancer, MCF-7, and epithelial normal, MCf-10A, cells. Methods: Free radical scavenging and total antioxidant capacities of herbal waters assessed by DPPH and FRAP methods, respectively. Their total phenolic contents and cell viability determined by Folin–Ciocalteu and MTT assays, respectively. Results: Among the herbs, group A which contained relatively highest total phenolics content, antioxidant and free radical scavenging activities inhibited significantly greater growth of breast cancer cells in a dose- and time-dependent manner as compared to other groups. These medicinal plants were not cytotoxic components against normal cells. Conclusion: Therefore our results indicated that anti proliferative effects of 12 selected Iranian herbs showed a direct correlation with antioxidant properties. The herbs as natural antioxidants with fewer side effects could potentially improve the outcome of human breast cancer therapy. These findings endorse further investigations on these plants to determine their active metabolites and mode of action.

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Percentage of DPPH radical quenching activity of similar concentrations of herbal extracts (0.5 g/l). Data are presented as means ± SEM (n = 3), and histograms marked with * are significantly different at P<0.05. Group A) 1.Rosmarinus officinalis 2.Ephedra sarcocarpa 3.Hymenocrater platystegius 4.Nepeta bracteata. Group B) 1.Tribulus terrestris 2.Avena fatus 3.Cichorium intybus 4. Ziziphora tenuir. Group C) 1.Solanum nigrum 2.Foeniculum vulgare 3.Achillea wilhelmsii 4.Cardaria drabal

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Published

2015-05-30

How to Cite

Hoshyar, R., Elham Mostafavinia, S. ., Zarban, A. ., Hassanpour, M. ., Partovfari, M. ., Taheri, A. ., & Pouyan, M. . (2015). Correlation of Anticancer Effects of 12 Iranian Herbs on Human breast Adenocarcinoma cells with antioxidant Properties. Free Radicals and Antioxidants, 5(2), 65–73. https://doi.org/10.5530/fra.2015.2.4