@article{Pawan Kumar Verma_Rajinder Raina_Mudasir Sultana_Shahid Prawez_Neha Jamwal_2013, title={Hepatoprotective mechanisms of Ageratum conyzoides L. on oxidative damage induced by acetaminophen in Wistar rats}, volume={3}, url={https://antiox.org/index.php/fra/article/view/189}, abstractNote={<p><strong>Background and objectives:</strong> Drug induced hepatotoxicity is a major health issue concern by drug regulatory agencies, pharmaceutical industry and health care professionals. Present study was aimed to investigate the hepatoprotective mechanisms of n-hexane and acetone extract of <em>Ageratum conyzoides</em> on oxidative damage induced by acetaminophen (APAP) in Wistar rats. <strong>Materials and methods:</strong> 42 Wistar rats were randomly divided into seven groups. Group I and II receive distilled water, CMC respectively. Group III was fed with standard drug silymarin, group IV and V received plant extracts only whereas group VI and VII received pretreatment with acetone and n-hexane extracts for seven days respectively and APAP was administered on the 5th day. Samples were collected on 48 h of post APAP administration and analysis was done using standard protocols. <strong>Results:</strong> Significant (<em>p</em> < 0.05) increased in MDA, G6PD and GST and significant (<em>p</em> < 0.05) decrease in SOD, GSH, total thiols in liver tissue was observed in APAP exposed group as compared to control. The preexposure of acetone and n-hexane extracts of <em>A. conyzoides</em> fallowed by APAP exposure significantly (<em>p</em> < 0.05) reduce activities of G6PD, GST and MDA levels as compare to APAP exposed group, whereas total thiols and GSH levels are restored only in n-hexane extract of <em>A. conyzoides</em>. <strong>Conclusion:</strong> Observations of present study suggested that pre-exposure of n-hexane extract of <em>A. conyzoides</em> restore the levels of total thiols, GSH and GST activity which may be responsible for reducing oxidative damage induced by APAP administration.</p>}, number={2}, journal={Free Radicals and Antioxidants}, author={Pawan Kumar Verma and Rajinder Raina and Mudasir Sultana and Shahid Prawez and Neha Jamwal}, year={2013}, month={Aug.}, pages={73–76} }