@article{R Patel_K Patel_2012, title={In vivo Anti-oxidant Activity of Dhatrinisha churna and Manjisthadi churna in High Fat Diet Induced Oxidative Stress}, volume={2}, url={https://antiox.org/index.php/fra/article/view/259}, DOI={10.5530/ax.2012.2.2.4}, abstractNote={<p><strong>Background:</strong> Dhatrinisha churna and Manjisthadi churna have been traditionally used in the Ayurvedic system of medicine and by traditional medical practicioners of India to treat hyperlipidemia. <strong>Objective:</strong> To evaluate the antioxidant activity of Dhatrinisha churna and Manjisthadi churna in experimental hyperlipidemic rats.<strong> Materials and Methods:</strong> Hyperlipidemia was induced by administrating exogenous cholesterol. Assessment of anti-oxidant status for liver was carried out by assay of various physiological enzymatic (like SOD, catalase, gluatathione peroxidase) and non enzymatic (GSH, lipid peroxidative indices) antioxidant. <strong>Result:</strong> Significant increase in the level of enzymes like SOD, catalase, glutathione peroxidase, GSH and decrease in lipid peroxidase were observed in drug treated animals.<strong> Conclusion:</strong> In conclusion, these observations show that Manjisthadi churna and Dhatrinisha churna exert their protective effect by improving antioxidant status and decreasing the lipid peroxidation, thus establishing them as an effective antioxidant.</p>}, number={2}, journal={Free Radicals and Antioxidants}, author={R Patel, Vishal and K Patel, Rakesh}, year={2012}, month={Apr.}, pages={19–23} }