@article{Parimi_Kolli_2012, title={Antibacterial and Free Radical Scavenging Activity of Michelia champaca Linn. Flower Extracts}, volume={2}, url={https://antiox.org/index.php/fra/article/view/272}, DOI={10.5530/ax.2012.2.10}, abstractNote={<p><strong>Introduction:</strong> <em>Michelia champaca</em> (Magnoliaceae) is a medicinal plant of paramount importance which is traditionally used against a number of diseases including inflammatory conditions. In the present study, crude hexane, ethyl acetate extracts and compounds 1-3 isolated from the extracts of <em>M. champaca</em> flower were investigated for possible antioxidant and antibacterial activity. <strong>Method:</strong> The DPPH radical scavenging assay was carried out by the protocol given by Nickavar et al 2006.<sup>[1]</sup> The extracts and the compounds were also investigated for antibacterial activity through disc diffusion method against four different bacterial strains viz. <em>Bacillus subtilis, Staphylococcus aureus, Salmonella typhi</em> and <em>Shigella dysenteriae</em> using ampicillin as control. <strong>Results:</strong> In the present study the ethyl acetate extract, hexane extract exhibited strong antioxidant activity and the IC<sub>50</sub> values in DPPH radical scavenging assay were found to be 160 μg/ml and 250 μg/ml, respectively while the IC<sub>50</sub> values of isolated compounds 1-3 were 200 μg/ml, 220 μg/ml and 150 μg/ ml, respectively. In this bioassay the extracts showed significant results compared to the individual isolated compounds. Ethyl acetate extract was more effective against all the bacterial strains followed by the hexane extract, compound-3, compound-1 and compound-2. Results of the present study suggest that <em>M. champaca</em> flower extracts and the isolated compounds possess strong antioxidant and antibacterial activity.</p>}, number={2}, journal={Free Radicals and Antioxidants}, author={Parimi, Umadevi and Kolli, Deephi}, year={2012}, month={Apr.}, pages={58–61} }