@article{Tsompos_Constantinos Panoulis_Aggeliki Triantafyllou_Constantinos Zografos_George C. Zografos_Apostolos Papalois_2024, title={Comparative Hypertestosteronemic Effects of the Erythropoietin and the U-74389G}, volume={14}, url={https://antiox.org/index.php/fra/article/view/369}, DOI={10.5530/fra.2024.1.4}, abstractNote={<p><strong>Background:</strong> This study is to find out in which direction two antioxidant promising molecules, the erythropoietin and the U-74389G, affect serum Testosterone (T) levels and what the magnitude of this alteration is. The posttreatment effects on serum Testosterone (T) levels were calculated, separately by each drug and afterwards a comparative calculation was following. <strong>Objectives:</strong> The estimation was extracted by the results of the 2 previous studies, each of which had estimated a certain influence, after the respective drug administration in an induced Ischemia-Reperfusion (IR) rat experiment. Materials and Methods: The 2 temporal experimental endpoints at which the serum T levels were measured were the 60th reperfusion min (for the 3 groups A, C and E) as well the 120th reperfusion min (for the other 3 groups B, D and F). Especially, the groups A and B were the placebo ones, the groups C and D were the post Epo; whereas the groups E and F were the post L administration. <strong>Results:</strong> The first previous study of Epo presented a non-significant hypertestosteronemic effect by 0.276%±0.272% (p-value=0.3006). Similarly, the second previous study of U-74389G presented also a non-significant hypertestosteronemic effect by 0.111%±0.179% (p-value=0.5245). The results of these 2 studies co-calculated as belonging to the same experimental setting, provided the outcome of L being just by 0.4046004 [0.4035126 - 0.4056911] less hypertestoteronemic than Epo (p-value=0.0000). <strong>Conclusion:</strong> The intrinsic antioxidant capacity of U-74389G ascribes just 0.4046004 [0.4035126 - 0.4056911] less hypertestoteronemic influence than Epo (p-value=0.0000).</p>}, number={1}, journal={Free Radicals and Antioxidants}, author={Tsompos, Constantinos and Constantinos Panoulis and Aggeliki Triantafyllou and Constantinos Zografos and George C. Zografos and Apostolos Papalois}, year={2024}, month={Sep.}, pages={27–31} }