TY - JOUR AU - Işil Yildirim, AU - Mustafa Karatepe, PY - 2014/07/09 Y2 - 2024/03/29 TI - The investigation of pro-oxidant: Effect of a new Schiff base and its metal complexes (Cu, Ni, Co, Zn, Mn) JF - Free Radicals and Antioxidants JA - Free Rad. Antiox. VL - 4 IS - 2 SE - Original Article DO - 10.5530/fra.2014.2.4 UR - https://antiox.org/index.php/fra/article/view/135 SP - 18-20 AB - <p><strong>Background:</strong> Multifarious biological activities of Schiff base (SB) derivatives are well-known. <strong>Aim:</strong> In this study aimed that investigation of pro-oxidant effect of ([(2-hydroxybenzylidene)-3methylurea]) derivative SB and its metal complexes. <strong>Material and Methods:</strong> Pro-oxidant effect was determined by antioxidant vitamins levels effect against malonyldialdehyde (MDA), which is an indicator of lipid peroxidation in the serum of rats. To this end; 4-6 weekly Wistar albino rats were injected 25 mg/L 2 weeks subcutaneously for 3 days apart by 1 ml injection of a new compound and were then sacrificed 16 days later. Effect of these compounds serum MDA concentration, which is an indicator of lipid peroxidation, serum antioxidant vitamins A, E, C levels were measured with high-performance liquid chromatograph. In the comparison done among a group. <strong>Result:</strong> It was observed that although other serum parameters were altered, groups in comparison with each other in the MDA, vitamins A, E and C concentrations were not statistically changed.<strong> Conclusion:</strong> It may conclude that the compounds tested the administered dose does not cause oxidative stress.</p> ER -