TY - JOUR AU - Olakunle Ajiboye, Taofeek AU - Toyin Yakubu, Musa AU - Temidayo Oladiji, Adenike PY - 2020/12/11 Y2 - 2024/03/29 TI - Electrophilic, Free Radical and Reactive Oxygen Species Scavenging and Detoxification Potentials of Lophiraalata Stem Bark Extract JF - Free Radicals and Antioxidants JA - Free Rad. Antiox. VL - 1 IS - 3 SE - Original Article DO - 10.5530/ax.2011.3.6 UR - https://antiox.org/index.php/fra/article/view/200 SP - 40-47 AB - <p>The electrophilic, free radical and reactive oxygen species scavenging and detoxification potentials of Lophiraalata stem bark was evaluated. <em>L. alata</em> stem bark effectively scavenged DPPH radical, superoxideion and hydrogen peroxide. It produced 88% scavenging effect of DPPH radical at a concentration of 1.0 mg/ml. Aqueous extract of <em>L. alata</em>-stem bark produced 76% and 92% scavenging effect on superoxide ion and hydrogen peroxide respectively at 1.0 mg/ml, which compared favourably with the synthetic antioxidant (butylated hydroanisole and α-tocopherol). A reducing power of<em> L. alata</em> stem bark was examined using K<sub>3</sub>Fe(CN)<sub>6</sub>, 2-folds reducing power potentials was exhibited by <em>L. alata</em> stem bark when compared with the synthetic antioxidant,butylated hydroanisole. Reactive oxygen species detoxify enzymes; superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase (GPx) and glutathione reductase (GRed) were significantly induced by 90, 133, 90 and 172% respectively. While the electrophilic detoxifying enzymes NADPH: quinone oxidoreductase-1 (NQO1), uridyl diphosphoglucuronosyl transferase (UGT), glutathione S- transferase (GST) and epoxide hydrolase (EPh)) were induced by 240, 81, 196 and 281% respectively at the end of the experimental period. In view of these properties, <em>L. alata</em> can act as a prophylactic by intervening as electrophilic, free radical and ROS scavenger and detoxifier.</p> ER -