TY - JOUR AU - R Patel, Vishal AU - K Patel, Rakesh PY - 2012/04/30 Y2 - 2024/03/29 TI - In vivo Anti-oxidant Activity of Dhatrinisha churna and Manjisthadi churna in High Fat Diet Induced Oxidative Stress JF - Free Radicals and Antioxidants JA - Free Rad. Antiox. VL - 2 IS - 2 SE - Research Article DO - 10.5530/ax.2012.2.2.4 UR - https://antiox.org/index.php/fra/article/view/259 SP - 19-23 AB - <p><strong>Background:</strong> Dhatrinisha churna and Manjisthadi churna have been traditionally used in the Ayurvedic system of medicine and by traditional medical practicioners of India to treat hyperlipidemia. <strong>Objective:</strong> To evaluate the antioxidant activity of Dhatrinisha churna and Manjisthadi churna in experimental hyperlipidemic rats.<strong> Materials and Methods:</strong> Hyperlipidemia was induced by administrating exogenous cholesterol. Assessment of anti-oxidant status for liver was carried out by assay of various physiological enzymatic (like SOD, catalase, gluatathione peroxidase) and non enzymatic (GSH, lipid peroxidative indices) antioxidant. <strong>Result:</strong> Significant increase in the level of enzymes like SOD, catalase, glutathione peroxidase, GSH and decrease in lipid peroxidase were observed in drug treated animals.<strong> Conclusion:</strong> In conclusion, these observations show that Manjisthadi churna and Dhatrinisha churna exert their protective effect by improving antioxidant status and decreasing the lipid peroxidation, thus establishing them as an effective antioxidant.</p> ER -