The investigation of pro-oxidant: Effect of a new Schiff base and its metal complexes (Cu, Ni, Co, Zn, Mn)

Authors

  • Işil Yildirim Department of Chemistry, Science Institute Firat University, 23200 Elazig, Turkey
  • Mustafa Karatepe Department of Chemistry, Science Institute Firat University, 23200 Elazig, Turkey

DOI:

https://doi.org/10.5530/fra.2014.2.4

Keywords:

Antioxidant vitamins (A, E, C), High-performance liquid chromatograph, Malonyldialdehyde, Schiff base

Abstract

Background: Multifarious biological activities of Schiff base (SB) derivatives are well-known. Aim: In this study aimed that investigation of pro-oxidant effect of ([(2-hydroxybenzylidene)-3methylurea]) derivative SB and its metal complexes. Material and Methods: Pro-oxidant effect was determined by antioxidant vitamins levels effect against malonyldialdehyde (MDA), which is an indicator of lipid peroxidation in the serum of rats. To this end; 4-6 weekly Wistar albino rats were injected 25 mg/L 2 weeks subcutaneously for 3 days apart by 1 ml injection of a new compound and were then sacrificed 16 days later. Effect of these compounds serum MDA concentration, which is an indicator of lipid peroxidation, serum antioxidant vitamins A, E, C levels were measured with high-performance liquid chromatograph. In the comparison done among a group. Result: It was observed that although other serum parameters were altered, groups in comparison with each other in the MDA, vitamins A, E and C concentrations were not statistically changed. Conclusion: It may conclude that the compounds tested the administered dose does not cause oxidative stress.

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Serum levels of MDA and vitamins in the rats treated with ligand and its complexes

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Published

2014-07-09

How to Cite

Işil Yildirim, & Mustafa Karatepe. (2014). The investigation of pro-oxidant: Effect of a new Schiff base and its metal complexes (Cu, Ni, Co, Zn, Mn). Free Radicals and Antioxidants, 4(2), 18–20. https://doi.org/10.5530/fra.2014.2.4