Antioxidant, Anti-inflammatory, Antiproliferative and Antimicrobial Activities of Combretum glutinosum and Gardenia aqualla Extracts in vitro

Authors

  • Bawa Yusuf Muhammad [1] Department of Biochemistry, Faculty of Science, Alexandria University, Alexandria, EGYPT. [2] Department of Biochemistry and Molecular Biology, Faculty of Science, Nasarawa State University Keffi, NIGERIA.
  • Nadia Zaky Shaban Department of Biochemistry, Faculty of Science, Alexandria University, Alexandria, EGYPT.
  • Fatima Hassan Elrashidy Department of Biochemistry, Faculty of Science, Alexandria University, Alexandria, EGYPT.
  • Doaa Ahmed Ghareeb [1] Department of Biochemistry, Faculty of Science, Alexandria University, Alexandria, EGYPT. [3] Bioanalytical centres of Excellence: Pharmaceutical and fermentation Department, GEBRI, SRAT-city, Alexandria, EGYPT.

DOI:

https://doi.org/10.5530/fra.2019.2.12

Keywords:

Antioxidant, Cytotoxicity, Cancer cell line, Anti-microbial, Drug discovery

Abstract

Objectives: Plants represent a diverse template that could be tapped as sources of novel drugs. This study highlights antioxidant, anti-inflammatory, anti-proliferative and as well antimicrobial activities of Combretum glutinosum (BE) and Gardenia aqualla (GE) roots ethanol extracts. Methods: The Biological activities were evaluated using the established standard methods. Results: Both extracts exhibited antioxidant and anti-inflammatory activities with BE being better than GE. Anti-proliferative (cytotoxicity) assay on HepG2 and BHK-21 cell lines similarly revealed that BE (IC50: 55, SI: 1.81) is more cytotoxic and more selective than GE (IC50: 478.60, SI: 0.99). For the antimicrobial study, BE inhibited the growth of pathogenic bacteria; Pseudomonas aeruginosa, Staphylococcus aureus, Vibrio species and E. coli, while GE extract showed activity against Candida albicans. Conclusion: We conclude that Combretum glutinosum extract (BE) possessed the most robust activity from this study. Hence, it could be a promising source of novel drug with wide biological activities, especially antioxidant and anticancer activities.

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Antioxidant, Anti-inflammatory, Antiproliferative and Antimicrobial Activities of Combretum glutinosum and Gardenia aqualla Extracts in vitro

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Published

2019-12-01
CITATION
DOI: 10.5530/fra.2019.2.12
Published: 2019-12-01

How to Cite

Muhammad, B. Y., Shaban, N. Z., Elrashidy, F. H., & Ghareeb, D. A. (2019). Antioxidant, Anti-inflammatory, Antiproliferative and Antimicrobial Activities of Combretum glutinosum and Gardenia aqualla Extracts in vitro. Free Radicals and Antioxidants, 9(2), 66–72. https://doi.org/10.5530/fra.2019.2.12