Efficacy of treatment on antioxidant status in cervical cancer patients: A case control study

Authors

  • Subramanyam Dasari Department of Biotechnology, Dravidian University, Kuppam 517 426, A.P., India
  • Rajendra Wudayagiri Department of Zoology, Sri Venkateswara University, Tirupati 517 502, A.P., India
  • Lokanatha Valluru Department of Biotechnology, Dravidian University, Kuppam 517 426, A.P., India

Keywords:

Antioxidant enzymes , Cervical cancer , Chemotherapy , Free radicals , Lipid peroxidation

Abstract

Background and aim: To evaluate the effect of treatment on antioxidant status of cervical cancer patients with suspected and healthy. Method: The study was included 59 cancer patients with cervical cancer were compared to suspected (n = 25) and healthy controls (n = 25). Of the 59, 30 patients undergoing chemotherapy alone, for 3 months and 29 patients were undergoing radiotherapy along with chemotherapy. Blood samples were collected after the treatment from all the groups and estimated the level of serum malondialdehyde, non-enzymatic antioxidant glutathione and enzymatic antioxidant including super oxide dismutase, catalase, glutathione peroxidase, glutathione reductase, glutathione-S-transferase and glucose-6- phosphate dehydrogenase. Results: The levels of serum malondialdehyde and glutathione reductase were significantly (P < 0.05) increased and all antioxidant enzymes were decreased in cervical cancer patients when compared to normal controls and suspected cases. The estimated antioxidant status was increased significantly after the treatment of radiotherapy along with chemotherapy than the chemotherapy alone. Conclusion: The results suggest that the elevated lipid peroxidation and impaired antioxidant status was significantly increased after the radiotherapy with chemotherapy than the chemotherapy alone.

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Osmotic fragility curves of normal, suspected and cervical cancer patients. The degree of haemolysis was calculated by comparing with 0.1% NaCl solution which represented 100% lysis.

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Published

2013-08-23

How to Cite

Subramanyam Dasari, Rajendra Wudayagiri, & Lokanatha Valluru. (2013). Efficacy of treatment on antioxidant status in cervical cancer patients: A case control study. Free Radicals and Antioxidants, 3(2), 87–92. Retrieved from https://antiox.org/index.php/fra/article/view/196