Superoxide Dismutase Ameliorates the Bowel Alterations Induced by Diabetes Mellitus – An Experimental Study

Authors

  • Henrique Fillmann Hospital de Clínicas de Porto Alegre
  • Juliana Tieppo Hospital de Clínicas de Porto Alegre,
  • Nélson Alexandre Kretzmann Filho Hospital de Clínicas de Porto Alegre
  • Graziella Rodrigues Hospital de Clínicas de Porto Alegre,
  • Jaqueline Nascimento Picada Universidade Luterana do Brasil, ULBRA,
  • Julian Panés Hospital Clínic. University of Barcelona,
  • Norma Possa Marroni 1Hospital de Clínicas de Porto Alegre, 2Universidade Luterana do Brasil, ULBRA,

DOI:

https://doi.org/10.5530/ax.2011.3.4

Keywords:

Oxidative stress, Diabetes, Superoxide dismutase

Abstract

Introduction: The gastrointestinal system is frequently affected in patients with diabetes mellitus (DM). Some of these alterations are due to oxidative stress and the production of free radicals. The present study was designed to evaluate whether treatment with superoxide dismutase (SOD) exerts protection on established bowel alterations in experimental diabetes mellitus induced by streptozotocin. We measured the lipid peroxidation, the superoxide dismutase activity and the DNA damage. Materials and Methods: We used the anorectal pressure to evaluate the nitrosative stress and used an inflammatory score to measure the macroscopic and microscopic bowel alterations. Results: The oxidative stress and the DNA damage was elevated in DM group and reduced with the SOD administration. The use of SOD also ameliorates the inflammatory bowel alterations and the anorectal pressure. Conclusion: SOD administration showed beneficial effects in all parameters of large bowel alterations in DM rats.

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The sphincteric anal pressure was measured through a manometric equipment with a balloon catheter (Proctossystem Viotti, Sao Paulo, Brazil)

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Published

2020-12-11

How to Cite

Fillmann, H. ., Tieppo, J. ., Alexandre Kretzmann Filho, N. ., Rodrigues, G. ., Nascimento Picada, J. ., Panés, J., & Possa Marroni, N. . (2020). Superoxide Dismutase Ameliorates the Bowel Alterations Induced by Diabetes Mellitus – An Experimental Study. Free Radicals and Antioxidants, 1(3), 19–26. https://doi.org/10.5530/ax.2011.3.4