In vivo Anti-oxidant Activity of Dhatrinisha churna and Manjisthadi churna in High Fat Diet Induced Oxidative Stress

Authors

  • Vishal R Patel Baroda College of Pharmacy, Parul Institute, Limda (Vadodara), Gujarat,
  • Rakesh K Patel S. K. Patel College of Pharmaceutical Education and Research, Ganpat University, Kherva (Mehsana), Gujarat,

DOI:

https://doi.org/10.5530/ax.2012.2.2.4

Keywords:

Manjisthadi churna, Dhatrinisha churna, Anti-oxidant activity

Abstract

Background: Dhatrinisha churna and Manjisthadi churna have been traditionally used in the Ayurvedic system of medicine and by traditional medical practicioners of India to treat hyperlipidemia. Objective: To evaluate the antioxidant activity of Dhatrinisha churna and Manjisthadi churna in experimental hyperlipidemic rats. Materials and Methods: Hyperlipidemia was induced by administrating exogenous cholesterol. Assessment of anti-oxidant status for liver was carried out by assay of various physiological enzymatic (like SOD, catalase, gluatathione peroxidase) and non enzymatic (GSH, lipid peroxidative indices) antioxidant. Result: Significant increase in the level of enzymes like SOD, catalase, glutathione peroxidase, GSH and decrease in lipid peroxidase were observed in drug treated animals. Conclusion: In conclusion, these observations show that Manjisthadi churna and Dhatrinisha churna exert their protective effect by improving antioxidant status and decreasing the lipid peroxidation, thus establishing them as an effective antioxidant.

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Effect of Manjisthadi churna and Dhatrinisha churna on SOD level of Liver tissues of different groups of rats (Units/mg protein)

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Published

2012-04-30

How to Cite

R Patel, V., & K Patel, R. (2012). In vivo Anti-oxidant Activity of Dhatrinisha churna and Manjisthadi churna in High Fat Diet Induced Oxidative Stress. Free Radicals and Antioxidants, 2(2), 19–23. https://doi.org/10.5530/ax.2012.2.2.4