Radical scavenging ability of glycyrrhizin

Authors

  • Kimie Imai Department of Clinical Pharmaceutics, Faculty of Pharmaceutical Sciences, Setsunan University, Hirakata, Osaka 573 0101, Japan
  • Yushi Takagi Department of Clinical Pharmaceutics, Faculty of Pharmaceutical Sciences, Setsunan University, Hirakata, Osaka 573 0101, Japan
  • Ayano Iwazaki Department of Clinical Pharmaceutics, Faculty of Pharmaceutical Sciences, Setsunan University, Hirakata, Osaka 573 0101, Japan
  • Kunio Nakanishi Department of Clinical Pharmaceutics, Faculty of Pharmaceutical Sciences, Setsunan University, Hirakata, Osaka 573 0101, Japan

Keywords:

Glycyrrhizin , (Gly) Glycyrrhezic acid (GA), Hydroxyl radical , Superoxide anion radical , 1,1-Diphenyl-2-picrylhydrazyl (DPPH)

Abstract

Glycyrrhizin (Gly), a major constituent of licorice root, has been used for the treatment of chronic liver diseases in Japan. Reports have been contradictory as to whether Gly scavenges hydroxyl radicals and superoxide anion radicals.We examined the radical scavenging abilities of Gly and glycyrrhezic acid (GA), an aglycon of Gly. Gly and GA did not scavenge hydroxyl radicals or superoxide anion radicals, but both scavenged 1,1-diphenyl-2-picrylhydrazyl (DPPH) radicals, in contrast to previous reports. The scavenging abilities of Gly and GA might play a role in the treatment of chronic liver diseases.

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OH radical scavenging ability of Gly and GA. Data represent the mean with SD (n ¼ 2e3). *p < 0.05.

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Published

2013-03-29

How to Cite

Kimie Imai, Yushi Takagi, Ayano Iwazaki, & Kunio Nakanishi. (2013). Radical scavenging ability of glycyrrhizin. Free Radicals and Antioxidants, 3(1), 40–42. Retrieved from https://antiox.org/index.php/fra/article/view/229