Radical scavenging ability of glycyrrhizin

Authors

  • Kimie Imai Department of Clinical Pharmaceutics, Faculty of Pharmaceutical Sciences, Setsunan University, Hirakata, Osaka 573 0101, Japan
  • Yushi Takagi Department of Clinical Pharmaceutics, Faculty of Pharmaceutical Sciences, Setsunan University, Hirakata, Osaka 573 0101, Japan
  • Ayano Iwazaki Department of Clinical Pharmaceutics, Faculty of Pharmaceutical Sciences, Setsunan University, Hirakata, Osaka 573 0101, Japan
  • Kunio Nakanishi Department of Clinical Pharmaceutics, Faculty of Pharmaceutical Sciences, Setsunan University, Hirakata, Osaka 573 0101, Japan

Keywords:

Glycyrrhizin , (Gly) Glycyrrhezic acid (GA), Hydroxyl radical , Superoxide anion radical , 1,1-Diphenyl-2-picrylhydrazyl (DPPH)

Abstract

Glycyrrhizin (Gly), a major constituent of licorice root, has been used for the treatment of chronic liver diseases in Japan. Reports have been contradictory as to whether Gly scavenges hydroxyl radicals and superoxide anion radicals.We examined the radical scavenging abilities of Gly and glycyrrhezic acid (GA), an aglycon of Gly. Gly and GA did not scavenge hydroxyl radicals or superoxide anion radicals, but both scavenged 1,1-diphenyl-2-picrylhydrazyl (DPPH) radicals, in contrast to previous reports. The scavenging abilities of Gly and GA might play a role in the treatment of chronic liver diseases.

Downloads

Metrics

PDF views
185
Jul 2013Jan 2014Jul 2014Jan 2015Jul 2015Jan 2016Jul 2016Jan 2017Jul 2017Jan 2018Jul 2018Jan 2019Jul 2019Jan 2020Jul 2020Jan 2021Jul 2021Jan 2022Jul 2022Jan 2023Jul 2023Jan 2024Jul 2024Jan 2025Jul 2025Jan 202611
|
OH radical scavenging ability of Gly and GA. Data represent the mean with SD (n ¼ 2e3). *p < 0.05.

Downloads

Published

2013-03-29

How to Cite

Kimie Imai, Yushi Takagi, Ayano Iwazaki, & Kunio Nakanishi. (2013). Radical scavenging ability of glycyrrhizin. Free Radicals and Antioxidants, 3(1), 40–42. Retrieved from https://antiox.org/index.php/fra/article/view/229