Lipid peroxidation, superoxide dismutase and catalase co-relation in pulmonary and extra pulmonary tuberculosis

Authors

  • Shubhangi M Dalvi Assistant Professor, Department of Biochemistry, Grant Government Medical College and Sir J.J.Group of Hospitals Byculla Mumbai 400008,
  • Vinayak W Patil Professor & Head of department, Department of Biochemistry, Grant Government Medical College and Sir J.J.Group of Hospitals Byculla Mumbai 400008,
  • Nagsen N. Ramraje Professor &Head of department Pulmonology department, Grant Government Medical College and Sir J.J.Group of Hospitals Byculla Mumbai 400008,
  • Jaising M Phadtare Head of Pulmonology Department of G.T. Government Hospital and Professor, Grant Government Medical College and Sir J.J.Group of Hospitals Byculla Mumbai 400008

DOI:

https://doi.org/10.5530/ax.2012.4.1

Keywords:

Catalase, Immune system, Pulmonary and extra pulmonary tuberculosis, Superoxide dismutase

Abstract

Objective: Tuberculosis is an infectious disease caused by Mycobacterium tuberculosis affecting mainly the immune system in humans. This Study determines the malondialdehyde causing oxidation stress and blood levels of superoxide dismutase, catalase act as anti-oxidant. Materials and Methods: Study carried out in normal control subjects (n = 100), different categories of pulmonary in newly sputum culture positive diagnosed category I (n = 100), category II (n = 100), category III (n = 100). Extra pulmonary category I (n = 35) and pulmonary category I before and after six months of directly observed treatment, short course. Results: Malondialdehyde levels were significantly increased in pulmonary and extra pulmonary tuberculosis patients. The activity of superoxide dismutase, and catalase were found to be significantly decreased in subjects of all categories of pulmonary and extra tuberculosis pulmonary. Negative correlation between malondialdehyde content, with superoxide dismutase, and catalase was seen in pulmonary tuberculosis, P < 0.001. Conclusion: Increased defense mechanism was due to increased oxidative stress in tuberculosis. Superoxide dismutase and catalase by scavenging of free oxygen radicals interrupt inflammatory cascades and thereby limit further disease progression. The changes were reversed after six month anti-tubercular treatment in patients with good recovery but increase oxidative stress was not completely reversed.

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Scatter diagram of serum malondialdehyde and in superoxide dismutase category I pulmonary tuberculosis untreated.

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Published

2012-12-29

How to Cite

Shubhangi M Dalvi, Vinayak W Patil, Nagsen N. Ramraje, & Jaising M Phadtare. (2012). Lipid peroxidation, superoxide dismutase and catalase co-relation in pulmonary and extra pulmonary tuberculosis. Free Radicals and Antioxidants, 2(4), 1–5. https://doi.org/10.5530/ax.2012.4.1