Regulation of Membrane Unsaturation as Antioxidant Adaptive Mechanism in Long-lived Animal Species

Authors

  • Alba Naudí Department of Experimental Medicine, University of Lleida-IRBLleida, Lleida 25008,
  • Victòria Ayala Department of Experimental Medicine, University of Lleida-IRBLleida, Lleida 25008,
  • Manuel Portero-Otín Department of Experimental Medicine, University of Lleida-IRBLleida, Lleida 25008,
  • Gustavo Barja Department of Animal Physiology II, Complutense University, Madrid 28040,
  • Reinald Pamplona Department of Experimental Medicine, University of Lleida-IRBLleida, Lleida 25008,
  • Reinald Pamplona Department of Experimental Medicine, University of Lleida-IRBLleida, Lleida 25008,

DOI:

https://doi.org/10.5530/ax.2011.3.2

Keywords:

Fatty acid desaturases, Membrane unsaturation, Oxidative damage, Peroxidizability index, Phylogenomic analysis, Reactive carbonyl species

Abstract

Oxidative stress resulting from biomolecular oxidative damage due to the imbalance between reactive species production and antioxidant response has become an universal constraint of life-history evolution in animals and a modulator of phenotypic development and trade-offs. Redox balance is an important selective pressure faced by most organisms, and a myriad of mechanisms have evolved to regulate and adjust this balance. This diversity of mechanisms means that organisms have a great deal of flexibility in how they deal with reactive species challenges across time, conditions, and tissue types, as well as that different organisms may evolve different strategies for dealing with similar challenges. In the following paragraphs, we review the adaption of biological membranes as structural antioxidant defense against reactive species evolved by animals. In particular, it is our goal to describe the physiological mechanisms underlying the structural adaption of cellular membranes to oxidative stress, to explain the meaning of this adaptive mechanism, and to review the state of the art about the link between membrane composition and longevity of animal species.

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Published

2020-12-11

How to Cite

Naudí, A. ., Ayala, V., Portero-Otín, M. ., Barja, G., Pamplona, R., & Pamplona, R. (2020). Regulation of Membrane Unsaturation as Antioxidant Adaptive Mechanism in Long-lived Animal Species. Free Radicals and Antioxidants, 1(3), 3–12. https://doi.org/10.5530/ax.2011.3.2